The storyline of the game takes place between Resident Evil 4 and Resident Evil 5. In 2005, BSAA head Clive R. O\'Brian sends out Jill Valentine and her new partner, Parker Luciani, to search for Chris Redfield and his new partner, Jessica Sherawat. They have reportedly gone missing and lost contact with HQ during their mission to investigate Veltro\'s possible reappearance. Jill and Parker are sent to search for them at their last known location, the cruise ship SS Queen Zenobia. During their search, they encounter several B.O.W.s on the ship infected with the T-Abyss virus, a marine virus derived from the deadly T-Virus. They finally enter a room where they believe Chris is being held, realizing too late that it was all a trap. Chris and Jessica, meanwhile, find a base of operations for Veltro; the Valkoinen Mökki airstrip in the mountains. Being informed by O\'Brian that Jill and Parker are missing in the Mediterranean, they are redeployed to investigate their whereabouts.